1-[4-(4-hydroxyphenyl)-1-piperazinyl]-3-(1H-indol-3-yl)-1-propanone

1-[4-(4-hydroxyphenyl)-1-piperazinyl]-3-(1H-indol-3-yl)-1-propanone, also known as **SB-203580**, is a potent and selective inhibitor of **p38 MAP kinase**.

**Here's why it's important for research:**

* **Understanding p38 MAP Kinase:** p38 MAP kinase is a key enzyme involved in various cellular processes, including inflammation, cell survival, and stress responses. It plays a crucial role in mediating the production of inflammatory cytokines like TNF-α and IL-1β.
* **Inflammation and Disease:** Excessive or prolonged activation of p38 MAP kinase is implicated in several inflammatory diseases like rheumatoid arthritis, Crohn's disease, and sepsis.
* **Therapeutic Potential:** SB-203580 has been extensively studied as a potential therapeutic agent for inflammatory disorders. Its ability to selectively inhibit p38 MAP kinase offers a promising approach to targeting inflammation without interfering with other important cellular functions.

**Specific Research Applications:**

* **Drug Development:** SB-203580 has served as a lead compound for developing new and improved anti-inflammatory drugs. Research efforts focus on optimizing its pharmacokinetic properties and minimizing off-target effects.
* **Biological Research:** As a potent and specific inhibitor, SB-203580 is a valuable tool for researchers investigating the role of p38 MAP kinase in various biological processes. It allows scientists to study the effects of inhibiting p38 MAP kinase in cells and animal models.
* **Mechanism of Action:** Studies using SB-203580 have contributed to understanding the detailed mechanisms by which p38 MAP kinase regulates inflammation and other cellular functions.

**Important Note:** While SB-203580 shows promise as a therapeutic agent, its clinical development has been hindered by various factors, including poor oral bioavailability and potential side effects. Nevertheless, research into p38 MAP kinase inhibitors continues, with the goal of developing safer and more effective drugs for inflammatory diseases.